Heart failure (HF) affects 5.1 million individuals in the United States annually, and it’s one of the most frequent causes of hospitalizations.
Researchers have suggested that coenzyme Q10 (CoQ10) may be beneficial in HF patients by exerting 3 different mechanisms: increasing ATP generation and cellular energy, reducing oxidative stress, and stabilizing calcium-dependent ion channels in the myocardium.
The topic was reviewed in a new article that appeared in the August 2016 issue of Current Heart Failure Reports. Prepared by 2 researchers from Ochsner Clinical School-University of Queensland School of Medicine in New Orleans, the research indicated that CoQ10’s clinical utility is growing.
Several randomized, controlled trials [RCTs] have examined CoQ10 supplementation. The largest demonstrated that NYHA class III or IV HF patients had 50% fewer hospitalizations but no mortality benefit. However, other smaller trials haven’t shown benefit in cardiac function or exercise tolerance.
Three meta-analyses addressed some of the issues that the RCTs brought to light. They suggested that CoQ10 benefits hemodynamic parameters, but mortality benefit remains unclear.
Although CoQ10 appears to be safe, the American College of Cardiology and American Heart Association didn’t include it in their 2013 HF guidelines.
Study reveals cholesterol link in aggressive cancers
Tue 9 Aug 2016
The University of Queensland research has revealed how fats – including cholesterol – could increase the progression of aggressive cancers. UQ Diamantina Institute study leader Associate Professor Michelle Hill said the findings offered potential new treatment strategies and targets. “Our previous research showed a high cholesterol diet increased the spread of prostate cancer tumours to lymph nodes, lungs and bones,” Dr Hill said. “The new study has extended the results to melanoma, breast, ovarian and kidney cancers by analysing published data sets.” Dr Hill said cholesterol and other fats were essential components of cell membranes, and played a role in regulating processes such as cell migration and division. “Cholesterol makes specialised membrane regions which are important regulators of cell function, and our laboratory has been investigating how these membrane regions increase cancer progression,” Dr Hill said.